Tuesday, October 31, 2006
Monday, October 30, 2006
For you Ali,love you girl!!!
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Waste Not, Want Not: Role For Caveolin-3 In Muscular Dystrophy
Main Category: Muscular Dystrophy News
Article Date: 17 Oct 2006 - 15:00pm (PST)
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The muscular dystrophies are a group of genetic and hereditary diseases in which patients experience skeletal muscle weakness due to wasting and loss of muscle fibers. However, the signaling pathways involved in muscle wasting have remained elusive. Researchers have begun to focus on the potential role of proteins known as caveolins in muscle wasting. Caveolins come together to form a scaffold onto which many other types of signaling molecules can assemble at the cell plasma membrane. Caveolin-3 is a muscle-specific form of caveolins.
In a study appearing online on October 12, in advance of publication in the November print issue of the Journal of Clinical Investigation, Yoshihide Sunada and colleagues from Kawasaki Medical School, Japan, show that loss of caveolin-3 in a mouse model of muscular dystrophy increases the intracellular activity of myostatin - a known inhibitor of muscle growth - and leads to muscle wasting. Conversely, the authors demonstrated that inhibition of myostatin rescued the muscle wasting in these mice. The study indicates that overactivation of myostatin signaling plays an important role in the pathogenesis of muscular dystrophy in mice, and that a principal function of caveolin-3 in skeletal muscle is to inhibit myostatin signaling, thereby preventing muscle wasting. Future studies may show that myostatin inhibition may have potential as a promising therapy for patients with certain kinds of muscular dystrophy.
TITLE: Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition
AUTHOR CONTACT:
Yoshihide Sunada
Kawasaki Medical School, Kurashiki, Japan.
Waste Not, Want Not: Role For Caveolin-3 In Muscular Dystrophy
Main Category: Muscular Dystrophy News
Article Date: 17 Oct 2006 - 15:00pm (PST)
| email this article | printer friendly | view or write opinions |
Useful Article?
Digg It
Del.icio.us
The muscular dystrophies are a group of genetic and hereditary diseases in which patients experience skeletal muscle weakness due to wasting and loss of muscle fibers. However, the signaling pathways involved in muscle wasting have remained elusive. Researchers have begun to focus on the potential role of proteins known as caveolins in muscle wasting. Caveolins come together to form a scaffold onto which many other types of signaling molecules can assemble at the cell plasma membrane. Caveolin-3 is a muscle-specific form of caveolins.
In a study appearing online on October 12, in advance of publication in the November print issue of the Journal of Clinical Investigation, Yoshihide Sunada and colleagues from Kawasaki Medical School, Japan, show that loss of caveolin-3 in a mouse model of muscular dystrophy increases the intracellular activity of myostatin - a known inhibitor of muscle growth - and leads to muscle wasting. Conversely, the authors demonstrated that inhibition of myostatin rescued the muscle wasting in these mice. The study indicates that overactivation of myostatin signaling plays an important role in the pathogenesis of muscular dystrophy in mice, and that a principal function of caveolin-3 in skeletal muscle is to inhibit myostatin signaling, thereby preventing muscle wasting. Future studies may show that myostatin inhibition may have potential as a promising therapy for patients with certain kinds of muscular dystrophy.
TITLE: Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition
AUTHOR CONTACT:
Yoshihide Sunada
Kawasaki Medical School, Kurashiki, Japan.
Sunday, October 29, 2006
I love this site
Walking the Talk
Open Your Heart to Jesus
"I will sprinkle clean water upon you to cleanse you from all your impurities, and from all your idols I will cleanse you. I will give you a new heart and place a new spirit within you, taking from your bodies your stony hearts and giving you natural hearts. I will put my spirit within you and make you live by my statutes, careful to observe my decrees. You shall live in the land I gave your fathers you shall be my people, and I will be your God." (Ezekiel 36: 25-28)
It is impossible to be good and live a holy life without the help of the Holy Spirit. It is difficult to even have the desire to live a holy life without help. The reason we need to be holy and cleansed from all of our impurities is because we cannot enter heaven, a completely holy place, with even a spot of sin. Since the Bible says, "For all have sinned and fall short of the glory of God,: we are kidding ourselves if we think we live outside of this truth. Yes, you have sinned, so in and of yourself you are unable to go to heaven when you die. However, there is good news. A way has been made for you. This is the free gift of salvation offered to us through Jesus Christ's death on the cross. It is simple. Just receive it. Ask Jesus to come into your heart and be your Lord and Saviour. He will forgive you of all of your sins and give you egverlasting life.
He will take you out of your darkness and into his glorious light. You will be his child. He will give you the power to be holy and will transform you into his image. You will have the strength to be kind, patient, loving, and forgiving. You will then shine his glorious light to a dark world that needs the love of Jesus.
So, even if you have no desire to be holy and you are quite content muddling in the sin that is so familiar to you, this is not God's plan for your life. He has a higher calling for you. He wants you to be holy as Christ is holy. He wants you to be with him in heaven after you die and not go to hell in everlasting torment with Satan, his demons and all of those who have died in their sins. So shake out of your old habits and unhhealthy surroundings and receive Jesus. He wants to remove every area of darkness in your life and cleanse and heal you. Even Christians can be in bondage to sin. There may still be some areas of sin that you are enjoying from time to time and you don't really want the Lord to come in and change this area of your life. The flesh is still screaming for satisfaction, yet the Spirit of the Lord in you is grieved. Remember, if you even have one small chain of bondage to sin in your life, then you are still chained. Our enemy, Satan, is looking for any area he can grab hold of to tear us completely down. Don't forget that we are in a battle. He preys on your weaknesses. Jesus wants to set you free from every chain in your life. he came to set you completely free!
"To be in Christ means being a completely new creature. Everything of the old is gone, now everything is made anew." (2 Corinthians 5"17)
Ask the Lord to shine his light in every area of darkness in your life. Ask him to give you the desire to be holy. He will come in and bring his healing power to transform you into his image.
Cyndie Grozelle
Open Your Heart to Jesus
"I will sprinkle clean water upon you to cleanse you from all your impurities, and from all your idols I will cleanse you. I will give you a new heart and place a new spirit within you, taking from your bodies your stony hearts and giving you natural hearts. I will put my spirit within you and make you live by my statutes, careful to observe my decrees. You shall live in the land I gave your fathers you shall be my people, and I will be your God." (Ezekiel 36: 25-28)
It is impossible to be good and live a holy life without the help of the Holy Spirit. It is difficult to even have the desire to live a holy life without help. The reason we need to be holy and cleansed from all of our impurities is because we cannot enter heaven, a completely holy place, with even a spot of sin. Since the Bible says, "For all have sinned and fall short of the glory of God,: we are kidding ourselves if we think we live outside of this truth. Yes, you have sinned, so in and of yourself you are unable to go to heaven when you die. However, there is good news. A way has been made for you. This is the free gift of salvation offered to us through Jesus Christ's death on the cross. It is simple. Just receive it. Ask Jesus to come into your heart and be your Lord and Saviour. He will forgive you of all of your sins and give you egverlasting life.
He will take you out of your darkness and into his glorious light. You will be his child. He will give you the power to be holy and will transform you into his image. You will have the strength to be kind, patient, loving, and forgiving. You will then shine his glorious light to a dark world that needs the love of Jesus.
So, even if you have no desire to be holy and you are quite content muddling in the sin that is so familiar to you, this is not God's plan for your life. He has a higher calling for you. He wants you to be holy as Christ is holy. He wants you to be with him in heaven after you die and not go to hell in everlasting torment with Satan, his demons and all of those who have died in their sins. So shake out of your old habits and unhhealthy surroundings and receive Jesus. He wants to remove every area of darkness in your life and cleanse and heal you. Even Christians can be in bondage to sin. There may still be some areas of sin that you are enjoying from time to time and you don't really want the Lord to come in and change this area of your life. The flesh is still screaming for satisfaction, yet the Spirit of the Lord in you is grieved. Remember, if you even have one small chain of bondage to sin in your life, then you are still chained. Our enemy, Satan, is looking for any area he can grab hold of to tear us completely down. Don't forget that we are in a battle. He preys on your weaknesses. Jesus wants to set you free from every chain in your life. he came to set you completely free!
"To be in Christ means being a completely new creature. Everything of the old is gone, now everything is made anew." (2 Corinthians 5"17)
Ask the Lord to shine his light in every area of darkness in your life. Ask him to give you the desire to be holy. He will come in and bring his healing power to transform you into his image.
Cyndie Grozelle
Saturday, October 28, 2006
After more than a week and countless shots(needles) my migraine is finally gone.Now if only my back and hips would heal fast so i could actually sleep,without waking up like a bear.Life is pretty good with the return of Bill to Denny's tonight then off in the spring to apprentice under my uncle.The goods are doing great in school a few bumps with Jord but it is getting better.Then again my patience is alot better to.It's nice to see the rain however I hope it is gone come Halloween. Remember to turn your clocks back that's right we gain an hour of sleep,I'm all up for that!!!! Also please keep Lynne and her Mom in your prayers during this difficult and trying time.
Friday, October 27, 2006
The Strength of Compassion
BO'S TIP OF THE DAY: Be friendly to everyone. Those who deserve it the least need it the most.
"Never discourage anyone...who continually makes progress, no matter how slow." - Plato (427 BC - 347 BC)
October 24, 2006
The Strength Of Compassion
Coming At Conflict With An Open Heart
Conflict is an unavoidable part of our lives because our beliefs and modes of being often contrast powerfully with those of our loved ones, acquaintances, and associates. Yet for all the grief disagreements can cause, we can learn much from them. The manner in which we handle ourselves when confronted with anger or argument demonstrates our overall level of patience and the quality of our energetic states. To resolve conflict, no matter how exasperating the disagreement at hand, we should approach our adversary with an open heart laden with compassion. Judgments and blame must be cast aside and replaced with mutual respect. Conflict is frequently motivated by unspoken needs that are masked by confrontational attitudes or aggressive behavior. When we come at conflict with love and acceptance in our hearts, we empower ourselves to discover a means to attaining collective resolution.
The key to finding the wisdom concealed in conflict is to ask yourself why you clash with a particular person or situation. Your inner self or the universe may be trying to point you to a specific life lesson, so try to keep your ears and eyes open. Once you have explored the internal and external roots of your disagreement, make a conscious effort to release any anger or resentment you feel. As you do so, the energy between you and your adversary with change perceptibly, even if they are still operating from a more limited energy state. Consider that each of you likely has compelling reasons for thinking and feeling as you do, and accept that you have no power to change your adversary's mind. This can help you approach your disagreement rationally, with a steady voice and a willingness to compromise.
If you listen thoughtfully and with an empathetic ear during conflict, you can transform clashes into opportunities to compromise. Examine your thoughts and feelings carefully. You may discover stubbornness within yourself that is causing resistance or that you are unwittingly feeding yourself negative messages about your adversary. As your part in disagreements becomes gradually more clear, each new conflict becomes another chance to further hone your empathy, compassion, and tolerance. From a great friend
"Never discourage anyone...who continually makes progress, no matter how slow." - Plato (427 BC - 347 BC)
October 24, 2006
The Strength Of Compassion
Coming At Conflict With An Open Heart
Conflict is an unavoidable part of our lives because our beliefs and modes of being often contrast powerfully with those of our loved ones, acquaintances, and associates. Yet for all the grief disagreements can cause, we can learn much from them. The manner in which we handle ourselves when confronted with anger or argument demonstrates our overall level of patience and the quality of our energetic states. To resolve conflict, no matter how exasperating the disagreement at hand, we should approach our adversary with an open heart laden with compassion. Judgments and blame must be cast aside and replaced with mutual respect. Conflict is frequently motivated by unspoken needs that are masked by confrontational attitudes or aggressive behavior. When we come at conflict with love and acceptance in our hearts, we empower ourselves to discover a means to attaining collective resolution.
The key to finding the wisdom concealed in conflict is to ask yourself why you clash with a particular person or situation. Your inner self or the universe may be trying to point you to a specific life lesson, so try to keep your ears and eyes open. Once you have explored the internal and external roots of your disagreement, make a conscious effort to release any anger or resentment you feel. As you do so, the energy between you and your adversary with change perceptibly, even if they are still operating from a more limited energy state. Consider that each of you likely has compelling reasons for thinking and feeling as you do, and accept that you have no power to change your adversary's mind. This can help you approach your disagreement rationally, with a steady voice and a willingness to compromise.
If you listen thoughtfully and with an empathetic ear during conflict, you can transform clashes into opportunities to compromise. Examine your thoughts and feelings carefully. You may discover stubbornness within yourself that is causing resistance or that you are unwittingly feeding yourself negative messages about your adversary. As your part in disagreements becomes gradually more clear, each new conflict becomes another chance to further hone your empathy, compassion, and tolerance. From a great friend
Wednesday, October 25, 2006
Monday, October 23, 2006
Apparently it is normal to have a migraine this long
After having this migraine;I'm about ready to chop off my head.I just can't shake it no matter what I do or the Doctor's do. I feel that I might have to go into the hospital again,I feel like such a bother but the doctors and nurses say don't worry about it cause you are in a lot of pain.On the brighter side of things,Samm is doing great at school.Her drawings are getting better an better each day.Jordan is doing good too,if he would stop getting picked on.I have also managed with Lynne's help to fix up my blog.Thankx Bonnie for the idea of the clock,I liked yours so much that I wanted one to.Lynne thankyou for all of your help during the migraine battle,blessings luv yah
migrain oh migrain please go away
As you may tell i changed my template and my links are not posted,but will be shortly.SO it is official Bill is going back to work on Saturday.We are also going home for xmas with my dad,we haven't had xmas together in 17 years.This will be the first time he meets the children and the first time I meet my lil sis joyce.I have never been one to like xmas but i actually can't wait.Since wednesday I have had a horrible migraine and it won't go away,right now i feel like a pincushion.So it's back to the dr's for me.
Sunday, October 22, 2006
my monster name
| Your Monster Profile |
 Wild Nightmare You Feast On: Lasanga You Lurk Around In: Olive Gardens You Especially Like to Torment: Vegans |
Saturday, October 21, 2006
Migraines can go away
Well not much has been happening in our crazy world.Bill goes back to Denny's late nights again on the 27th(Yah)!!!After fighting a migraine for the past three days and nothing is helping i'm getting worried.My head hurts so much that all i want to do is sleep it off but that isn't helping either.With alot of bullying going on in todays society it brought me back to an old song.Just so you know I have never dealt drugs or done them,okay i tried once.So hope you can read between the lines in the song.
Tuesday, October 17, 2006
A song that gets me through the tough times
Cause I now know I can go home,however Terrace is our home now and we love it.Thankyou everyone for embracing us and letting us know we are not alone and home is truly where you make it.love you all
Life's little mysteries
wonder why we go through,everything we do? I realize that nothing is in our control but in God's hands. That without God our lives would be much more chaotic than they are already.I strongly believe that everything happens for a reason,sometimes I just wish we didn't have to wait so long to found out what God's reasons are. I mean I can't be the only person out there to wonder this old age question? Or am I? It took all of summer fighting allergies to find out today that my allergies are definatly caused by the mold inside my house,here I thought I had a bad viral infection and was being so careful not to catch spinal menengitis again.I love this time of year when the leaves are changing color,makes me appreciate life so much and how blessed I am.Update on my brother he is doing great,and my Mom and I are repairing our relationshiip.We will never fully agree on what is best for my brother so I have layed it down at the cross.I love him with all my heart and if anyone is my hero it is him,he has overcome so much and keeps on going with everything he has,he told me the other day Winners never Quit and Quitters never Win.There are days when I wish I could be more like him,always caring about everyone else,making sure we are okay. My brothers favorite song isn't it cool???My brother's favorite song,isn't that just too cool??
Saturday, October 14, 2006
Freaky Friday the 13th
Well nothing out of the ordinary happened today,kids had school,i went to work.It never fails i make arrangements for our family pics and the sunshine disappears.Hope it doesn't rain tommorrow.Trying to decide what to wear and what color,and i need to wear makeup to cover up my blemishes,circles under my eyes and also add color to myself.It has been two years since we did our pics last,so i'm a little excited.I will post some of them when they are ready.How was everyone else's day. first heard this song tonight and it touched me soo much suppossed to be teach me how to pray by jason uptown
Thursday, October 12, 2006
Just can't get enough of this weather;loving it
Today Lynne and I went for a walk across from ferry island,and yuck we found a moose head.(off of Queensway).At first we didn't know what it was,so we crept up to it slowly,which is funny as we knew what ever it was it was dead.We had such a blast.I can not believe how wonderful our afternoons are,so sunny and warm.I only hope the weather holds out for a little while longer so we can do our family pics on Sat.For all of you who are superstitious tommorrow is Friday the 13th.The last time we had a Friday the 13th in October I had my appendix taken out.That was too freaky for me.So I'm going to not even think about the date tommorrow.With Monday being a holiday the kids have school tommorrow which they aren't too happy about.I told them they are lucky cause when I went to school I went 5 days a week and was lucky to have a day off.If I remember right I think the only time I didn't have to go to school was when I was sick.However I know it must be harder than when I was in school,just cramming everything they need to learn in half the time.All in all it was a great day. Isn't Celine amazing,i just love her music
Wednesday, October 11, 2006
Talk about awesome weather
We have been having amazing weather.Can it really be October and be this nice out?I just love autumn,it is my favorite time of year.I just love the way the leaves change color,and when you rake up your yard then jump into the pile like when you were little.I believe that we all still have the little kid in us all.Snow angels is another favorite passtime in the winter.Everything for us has been great lately,aside from still being sick.Thanksgiving was very quiet and nice,gave the 4 of us a chance to catch up with each other.Much needed time spent together,you never realize just how busy everyone's life can be.It makes it that much nicer to be able to put away everyone's schedules for an entire evening and be able to enjoy true family time.Unfortunatly I forgot to pick up film so we have no pics of thanksgiving this year.Time for a digital camera I think. I just love this song,everytime I hear it I get goosebumps.Love and blessings to All
Monday, October 09, 2006
what 2004 song are you?
| 100 Years by Five for Fighting |
 "Every day's a new day... 15 there's still time for you Time to buy and time to choose Hey 15, there's never a wish better than this When you only got 100 years to live" 2004 was about thinking and reflecting - but isn't every year? |
thought i would check out what my elf name is;
Okay so I was curious about al
l of us;
The order is bill,myself,samm and jord
| Your Elf Name Is... |
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| Your Elf Name Is... |
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| Your Elf Name Is... |
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| Your Elf Name Is... |
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Sunday, October 08, 2006
For My Dad
Many of you know that my Dad has only recently entered my life again after almost 15 years.Bringing the joy of my two sisters into my life,for all of this I am grateful.I also remember the last time we danced as father,daughter.So Dad this is for you.Love you
What a great day
I am still sick but I had a great time today.I only wish that my head and chest cold would go away.I can not believe how sunny it was today,I just love autumn makes me appreciate life that much more.I am hoping it is nice next Saturday so we can get our family pics done by Starla again.Might be moving into another house,as the mold is soo bad in here,i'm sure it is toxic(it's black.)I don't have much to write about so I will leave with these words;
God has a thousand ways where I can see not one.when all my means have reached their end,Then his have just begune Esther Guyot
God has a thousand ways where I can see not one.when all my means have reached their end,Then his have just begune Esther Guyot
Saturday, October 07, 2006
Happy Thanksgiving
Well it is once again that time of year to reflect on what we are thankful for.Myself I am very thankful for many things,the most important is being one of god's children,then our children,my husband,my parents,my siblings, my family, church family and our lovely friends who are there no matter what good or bad and at any time day or night.I am thankful that my brother is still here with us.That my Dad has come back into our lives,the chance i've been givin to know my sisters.The rebuilding of my relationship with my Mom.I am also thankful that God has found has and called us to The Rock,where we feel at home and have so many wonderful brothers and sisters.So have a Happy Thanksgiving everyone.
Thursday, October 05, 2006
colds; a sign of autumn
Well after thinking i got rid of my cold,i didn't.I gave it to Jordan who gave it to Samm,then i got it back worse.So i'm off to the doctor's in the morning to see if there is anything he can do.I was really hoping to go to cell last night,but after work i just felt wiped right out.I am hoping to feel better to go to church on Sunday.It sure feels great to be slowly getting back into the loop of things.Jordan and Samm have adjusted well with going back to school.Just can't wait till xmas hopefully we can go and see my Dad and Stepmom,my sisters and my family.Right now I am searching for a car,4 door,standard or automatic and hopefully can make payments on.I know though all in god's time.
Sunday, October 01, 2006
Jordan's party(12) my little boy is growing up(oct3rd)
Well We survived Jordan's birthday party,it was such a blast.A bit noisy but what can you expect when you have 6 boys spend the night.They went swimming then hotdogs, cake.I even bought ice cream and one of the little guys said remember when you went out and you made sure you didn't forget something?I did i forgot to serve the ice cream (oops).Another sign I'm not perfect.I couldn't have asked for better behaved children.Jordan was given this cool game called Big Brain Academy it is so cool.I went to take pics and since i'm not with the times i ran out of film,so i have no pics at all.All in ALL it was an awesome time.
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